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Cruises Calling at Cape Girardeau

19 upcoming cruises that stop at Cape Girardeau, Missouri, USA. Updated regularly; always confirm with the cruise line.

Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 29 Jul 202621 nights18 portsDeparts 2026 Jul 18
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 18 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 19 JulDarrow LA, Louisiana
  3. 20 JulSt Francisville LA, Louisiana
  4. 21 JulNatchez MS, Mississippi
  5. 22 JulVicksburg MS, Mississippi
  6. 23 JulGreenville MS, Mississippi
  7. 25 Jul - 26 JulMemphis TN, Tennessee
  8. 28 JulPaducah KY, Kentucky
  9. 29 JulCape Girardeau MO, Missouri
  10. 30 Jul - 31 JulSt Louis MO, Missouri
  11. 01 AugAlton IL, Illinois
  12. 02 AugHannibal MO, Missouri
  13. 03 AugBurlington IA, Iowa
  14. 04 AugDavenport IA, Iowa, Quad Cities
  15. 05 AugDubuque IA, Iowa
  16. 06 AugLa Crosse WI, Wisconsin
  17. 07 AugRed Wing MN, Minnesota
  18. 08 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
Price on request
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 29 Jul 202614 nights11 portsDeparts 2026 Jul 18
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 18 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 19 JulDarrow LA, Louisiana
  3. 20 JulSt Francisville LA, Louisiana
  4. 21 JulNatchez MS, Mississippi
  5. 22 JulVicksburg MS, Mississippi
  6. 23 JulGreenville MS, Mississippi
  7. 25 Jul - 26 JulMemphis TN, Tennessee
  8. 28 JulPaducah KY, Kentucky
  9. 29 JulCape Girardeau MO, Missouri
  10. 30 Jul - 31 JulSt Louis MO, Missouri
  11. 01 AugArriving in Alton IL, Illinois
Find this cruise to book →
$8999from / pp
Viking Mississippi
Viking River Cruises
Memphis TN → Nashville TN
⚓ Calls 30 Oct 20265 nights5 portsDeparts 2026 Oct 28
View itinerary · 5 ports
5 days, one-way from Memphis TN to Nashville TN
  1. 28 OctDeparting from Memphis TN, Tennessee
  2. 30 OctCape Girardeau MO, Missouri
  3. 31 OctPaducah KY, Kentucky
  4. 01 NovClarksville TN, Tennessee
  5. 02 NovArriving in Nashville TN, Tennessee
Find this cruise to book →
$5799from / pp
Viking Mississippi
Viking River Cruises
Nashville TN → Memphis TN
⚓ Calls 07 Nov 20265 nights5 portsDeparts 2026 Nov 04
View itinerary · 5 ports
5 days, one-way from Nashville TN to Memphis TN
  1. 04 NovDeparting from Nashville TN, Tennessee
  2. 05 NovClarksville TN, Tennessee
  3. 06 NovPaducah KY, Kentucky
  4. 07 NovCape Girardeau MO, Missouri
  5. 09 NovArriving in Memphis TN, Tennessee
Find this cruise to book →
$5499from / pp
Viking Mississippi
Viking River Cruises
Memphis TN → Nashville TN
⚓ Calls 13 Nov 20265 nights5 portsDeparts 2026 Nov 11
View itinerary · 5 ports
5 days, one-way from Memphis TN to Nashville TN
  1. 11 NovDeparting from Memphis TN, Tennessee
  2. 13 NovCape Girardeau MO, Missouri
  3. 14 NovPaducah KY, Kentucky
  4. 15 NovClarksville TN, Tennessee
  5. 16 NovArriving in Nashville TN, Tennessee
Find this cruise to book →
$5299from / pp
Viking Mississippi
Viking River Cruises
Nashville TN → Memphis TN
⚓ Calls 21 Nov 20265 nights5 portsDeparts 2026 Nov 18
View itinerary · 5 ports
5 days, one-way from Nashville TN to Memphis TN
  1. 18 NovDeparting from Nashville TN, Tennessee
  2. 19 NovClarksville TN, Tennessee
  3. 20 NovPaducah KY, Kentucky
  4. 21 NovCape Girardeau MO, Missouri
  5. 23 NovArriving in Memphis TN, Tennessee
Find this cruise to book →
$4799from / pp
ACL American Melody
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 15 Jun 202721 nights18 portsDeparts 2027 Jun 05
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 05 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 05 JunNew Orleans, Port NOLA Louisiana
  3. 06 JunOak Alley Plantation, Louisiana
  4. 07 JunBaton Rouge, Louisiana
  5. 08 JunSt Francisville LA, Louisiana
  6. 09 JunNatchez MS, Mississippi
  7. 10 JunVicksburg MS, Mississippi
  8. 11 JunGreenville MS, Mississippi
  9. 12 JunTunica MS, Mississippi
  10. 13 JunMemphis TN, Tennessee
  11. 15 JunCape Girardeau MO, Missouri
  12. 17 JunSt Louis MO, Missouri
  13. 19 JunHannibal MO, Missouri
  14. 21 JunMuscatine IA, Iowa
  15. 22 JunDubuque IA, Iowa
  16. 24 JunWinona MN, Minnesota
  17. 25 JunRed Wing MN, Minnesota
  18. 26 JunArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
ACL American Serenade
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 22 Jun 202721 nights18 portsDeparts 2027 Jun 12
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 12 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 12 JunNew Orleans, Port NOLA Louisiana
  3. 13 JunOak Alley Plantation, Louisiana
  4. 14 JunBaton Rouge, Louisiana
  5. 15 JunSt Francisville LA, Louisiana
  6. 16 JunNatchez MS, Mississippi
  7. 17 JunVicksburg MS, Mississippi
  8. 18 JunGreenville MS, Mississippi
  9. 19 JunTunica MS, Mississippi
  10. 20 JunMemphis TN, Tennessee
  11. 22 JunCape Girardeau MO, Missouri
  12. 24 JunSt Louis MO, Missouri
  13. 26 JunHannibal MO, Missouri
  14. 28 JunMuscatine IA, Iowa
  15. 29 JunDubuque IA, Iowa
  16. 01 JulWinona MN, Minnesota
  17. 02 JulRed Wing MN, Minnesota
  18. 03 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 17 Jul 202714 nights11 portsDeparts 2027 Jul 06
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 06 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 07 JulDarrow LA, Louisiana
  3. 08 JulSt Francisville LA, Louisiana
  4. 09 JulNatchez MS, Mississippi
  5. 10 JulVicksburg MS, Mississippi
  6. 11 JulGreenville MS, Mississippi
  7. 13 Jul - 14 JulMemphis TN, Tennessee
  8. 16 JulPaducah KY, Kentucky
  9. 17 JulCape Girardeau MO, Missouri
  10. 18 Jul - 19 JulSt Louis MO, Missouri
  11. 20 JulArriving in Alton IL, Illinois
Find this cruise to book →
$9999from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 17 Jul 202721 nights18 portsDeparts 2027 Jul 06
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 06 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 07 JulDarrow LA, Louisiana
  3. 08 JulSt Francisville LA, Louisiana
  4. 09 JulNatchez MS, Mississippi
  5. 10 JulVicksburg MS, Mississippi
  6. 11 JulGreenville MS, Mississippi
  7. 13 Jul - 14 JulMemphis TN, Tennessee
  8. 16 JulPaducah KY, Kentucky
  9. 17 JulCape Girardeau MO, Missouri
  10. 18 Jul - 19 JulSt Louis MO, Missouri
  11. 20 JulAlton IL, Illinois
  12. 21 JulHannibal MO, Missouri
  13. 22 JulBurlington IA, Iowa
  14. 23 JulDavenport IA, Iowa, Quad Cities
  15. 24 JulDubuque IA, Iowa
  16. 25 JulLa Crosse WI, Wisconsin
  17. 26 JulRed Wing MN, Minnesota
  18. 27 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15998from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 21 Aug 202714 nights11 portsDeparts 2027 Aug 10
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 10 AugDeparting from New Orleans, Port NOLA Louisiana
  2. 11 AugDarrow LA, Louisiana
  3. 12 AugSt Francisville LA, Louisiana
  4. 13 AugNatchez MS, Mississippi
  5. 14 AugVicksburg MS, Mississippi
  6. 15 AugGreenville MS, Mississippi
  7. 17 Aug - 18 AugMemphis TN, Tennessee
  8. 20 AugPaducah KY, Kentucky
  9. 21 AugCape Girardeau MO, Missouri
  10. 22 Aug - 23 AugSt Louis MO, Missouri
  11. 24 AugArriving in Alton IL, Illinois
Find this cruise to book →
$9999from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 21 Aug 202721 nights18 portsDeparts 2027 Aug 10
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 10 AugDeparting from New Orleans, Port NOLA Louisiana
  2. 11 AugDarrow LA, Louisiana
  3. 12 AugSt Francisville LA, Louisiana
  4. 13 AugNatchez MS, Mississippi
  5. 14 AugVicksburg MS, Mississippi
  6. 15 AugGreenville MS, Mississippi
  7. 17 Aug - 18 AugMemphis TN, Tennessee
  8. 20 AugPaducah KY, Kentucky
  9. 21 AugCape Girardeau MO, Missouri
  10. 22 Aug - 23 AugSt Louis MO, Missouri
  11. 24 AugAlton IL, Illinois
  12. 25 AugHannibal MO, Missouri
  13. 26 AugBurlington IA, Iowa
  14. 27 AugDavenport IA, Iowa, Quad Cities
  15. 28 AugDubuque IA, Iowa
  16. 29 AugLa Crosse WI, Wisconsin
  17. 30 AugRed Wing MN, Minnesota
  18. 31 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$16498from / pp
ACL American Melody
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 13 Jun 202821 nights18 portsDeparts 2028 Jun 03
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 03 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 03 JunNew Orleans, Port NOLA Louisiana
  3. 04 JunOak Alley Plantation, Louisiana
  4. 05 JunBaton Rouge, Louisiana
  5. 06 JunSt Francisville LA, Louisiana
  6. 07 JunNatchez MS, Mississippi
  7. 08 JunVicksburg MS, Mississippi
  8. 09 JunGreenville MS, Mississippi
  9. 10 JunTunica MS, Mississippi
  10. 11 JunMemphis TN, Tennessee
  11. 13 JunCape Girardeau MO, Missouri
  12. 15 JunSt Louis MO, Missouri
  13. 17 JunHannibal MO, Missouri
  14. 19 JunMuscatine IA, Iowa
  15. 20 JunDubuque IA, Iowa
  16. 22 JunWinona MN, Minnesota
  17. 23 JunRed Wing MN, Minnesota
  18. 24 JunArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
ACL American Serenade
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 20 Jun 202821 nights18 portsDeparts 2028 Jun 10
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 10 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 10 JunNew Orleans, Port NOLA Louisiana
  3. 11 JunOak Alley Plantation, Louisiana
  4. 12 JunBaton Rouge, Louisiana
  5. 13 JunSt Francisville LA, Louisiana
  6. 14 JunNatchez MS, Mississippi
  7. 15 JunVicksburg MS, Mississippi
  8. 16 JunGreenville MS, Mississippi
  9. 17 JunTunica MS, Mississippi
  10. 18 JunMemphis TN, Tennessee
  11. 20 JunCape Girardeau MO, Missouri
  12. 22 JunSt Louis MO, Missouri
  13. 24 JunHannibal MO, Missouri
  14. 26 JunMuscatine IA, Iowa
  15. 27 JunDubuque IA, Iowa
  16. 29 JunWinona MN, Minnesota
  17. 30 JunRed Wing MN, Minnesota
  18. 01 JulArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 22 Jul 202814 nights11 portsDeparts 2028 Jul 11
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 11 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 12 JulDarrow LA, Louisiana
  3. 13 JulSt Francisville LA, Louisiana
  4. 14 JulNatchez MS, Mississippi
  5. 15 JulVicksburg MS, Mississippi
  6. 16 JulGreenville MS, Mississippi
  7. 18 Jul - 19 JulMemphis TN, Tennessee
  8. 21 JulPaducah KY, Kentucky
  9. 22 JulCape Girardeau MO, Missouri
  10. 23 Jul - 24 JulSt Louis MO, Missouri
  11. 25 JulArriving in Alton IL, Illinois
Find this cruise to book →
$9999from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 22 Jul 202821 nights18 portsDeparts 2028 Jul 11
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 11 JulDeparting from New Orleans, Port NOLA Louisiana
  2. 12 JulDarrow LA, Louisiana
  3. 13 JulSt Francisville LA, Louisiana
  4. 14 JulNatchez MS, Mississippi
  5. 15 JulVicksburg MS, Mississippi
  6. 16 JulGreenville MS, Mississippi
  7. 18 Jul - 19 JulMemphis TN, Tennessee
  8. 21 JulPaducah KY, Kentucky
  9. 22 JulCape Girardeau MO, Missouri
  10. 23 Jul - 24 JulSt Louis MO, Missouri
  11. 25 JulAlton IL, Illinois
  12. 26 JulHannibal MO, Missouri
  13. 27 JulBurlington IA, Iowa
  14. 28 JulDavenport IA, Iowa, Quad Cities
  15. 29 JulDubuque IA, Iowa
  16. 30 JulLa Crosse WI, Wisconsin
  17. 31 JulRed Wing MN, Minnesota
  18. 01 AugArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$16998from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Alton IL
⚓ Calls 26 Aug 202814 nights11 portsDeparts 2028 Aug 15
View itinerary · 11 ports
14 days, one-way from New Orleans to Alton IL
  1. 15 AugDeparting from New Orleans, Port NOLA Louisiana
  2. 16 AugDarrow LA, Louisiana
  3. 17 AugSt Francisville LA, Louisiana
  4. 18 AugNatchez MS, Mississippi
  5. 19 AugVicksburg MS, Mississippi
  6. 20 AugGreenville MS, Mississippi
  7. 22 Aug - 23 AugMemphis TN, Tennessee
  8. 25 AugPaducah KY, Kentucky
  9. 26 AugCape Girardeau MO, Missouri
  10. 27 Aug - 28 AugSt Louis MO, Missouri
  11. 29 AugArriving in Alton IL, Illinois
Find this cruise to book →
$9999from / pp
Viking Mississippi
Viking River Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 26 Aug 202821 nights18 portsDeparts 2028 Aug 15
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 15 AugDeparting from New Orleans, Port NOLA Louisiana
  2. 16 AugDarrow LA, Louisiana
  3. 17 AugSt Francisville LA, Louisiana
  4. 18 AugNatchez MS, Mississippi
  5. 19 AugVicksburg MS, Mississippi
  6. 20 AugGreenville MS, Mississippi
  7. 22 Aug - 23 AugMemphis TN, Tennessee
  8. 25 AugPaducah KY, Kentucky
  9. 26 AugCape Girardeau MO, Missouri
  10. 27 Aug - 28 AugSt Louis MO, Missouri
  11. 29 AugAlton IL, Illinois
  12. 30 AugHannibal MO, Missouri
  13. 31 AugBurlington IA, Iowa
  14. 01 SepDavenport IA, Iowa, Quad Cities
  15. 02 SepDubuque IA, Iowa
  16. 03 SepLa Crosse WI, Wisconsin
  17. 04 SepRed Wing MN, Minnesota
  18. 05 SepArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$16998from / pp
ACL American Melody
American Cruise Lines Cruises
New Orleans → Minneapolis-Saint Paul
⚓ Calls 19 Jun 202921 nights18 portsDeparts 2029 Jun 09
View itinerary · 18 ports
21 days, one-way from New Orleans to Minneapolis-Saint Paul
  1. 09 JunDeparting from New Orleans, Port NOLA Louisiana
  2. 09 JunNew Orleans, Port NOLA Louisiana
  3. 10 JunOak Alley Plantation, Louisiana
  4. 11 JunBaton Rouge, Louisiana
  5. 12 JunSt Francisville LA, Louisiana
  6. 13 JunNatchez MS, Mississippi
  7. 14 JunVicksburg MS, Mississippi
  8. 15 JunGreenville MS, Mississippi
  9. 16 JunTunica MS, Mississippi
  10. 17 JunMemphis TN, Tennessee
  11. 19 JunCape Girardeau MO, Missouri
  12. 21 JunSt Louis MO, Missouri
  13. 23 JunHannibal MO, Missouri
  14. 25 JunMuscatine IA, Iowa
  15. 26 JunDubuque IA, Iowa
  16. 28 JunWinona MN, Minnesota
  17. 29 JunRed Wing MN, Minnesota
  18. 30 JunArriving in Minneapolis-Saint Paul, Minnesota
Find this cruise to book →
$15890from / pp

Itineraries and prices change — always confirm with the cruise line before booking. Some links are affiliate links that may earn us a commission at no extra cost to you.